miR-96 has been shown to suppress PRMT5 translation in human B cell lymphoma cells and human and mouse PRMT5 3′UTRs are highly conserved at the predicted target regions of our miRNAs (Figure 4E), suggesting that miR-15a, miR-15b, miR-16, miR-140-3p, miR-322/424, and others could potentially regulate human PRMT5. Here, PRMT5 is linked to B-cell non-Hodgkin lymphoma.