CCNB1 and cancer: The top 1 network in the spleens of A.SW mice was categorized as “Cell Cycle,” “Reproductive System Development and Function,” and “Cancer,” including down-regulated genes: cyclin family (Ccne1, Ccnb1, and Ccnb2) and cell division cycle family (Cdc20, Cdc25b, and Cdc25c) (Figure 3E).