LRG1 and myeloid sarcoma: Thus, both supervised two-way comparison and unsupervised PCA showed that there were only three genes in common between the brains and spleens: Chil3, Serpina3n, and Lrg1. This could be consistent with a hypothesis that immune responses in progressive MS are sequestered from the systemic immune responses; the pathophysiology in the CNS at this stage may occur within the intact blood-brain barrier, and be independent of systemic immune responses (83).