Since testing for specific autoantibodies (extractable nuclear antigens, dsDNA, anti-phospholipid-antibodies, anti-proteinase 3- or anti-myeloperoxidase-antibodies) was positive in only 10% of the ANA-positive MS-patients, ANA-diagnostics should always comprise both, indirect immunofluorescence for screening and immunoblot/ELISA for differentiation of antibodies against nuclear antigens, to distinguish RDwCNS from ANA-positive MS. This evidence concerns the gene BTG3 and myeloid sarcoma.