ARHGEF2, RAC2, SEMA4D, PRKCD, GRB2, and DOCK2 were repeatedly enriched in important GO BP terms or KEGG pathways, such as “axon guidance,” “phagocytosis,” and “chemokine signaling,” which are all associated with the pathology of MS and MS process. Here, ARHGEF2 is linked to myeloid sarcoma.