FcγRIIA activation induces the production of pro-inflammatory cytokines, including IFN and TNFα, which are active in the promotion of inflammation, systemic lupus erythematosus (SLE), Kawasaki disease (KD), Grave's disease, and Rheumatoid Arthritis (RA) (35, 165–167). This evidence concerns the gene TNF and rheumatoid arthritis.