Of note, we observed a similar population of CD4+ TEMRA and TEM cells co-expressing CD57+ CX3CR1+ GPR56+ in matched PBMC samples which, again, increased with glucose intolerance and were significantly different between diabetic and non-diabetic PLWH (total CD4+ [p < 0.01], CD4+ TEM [p = 0.05] and CD4+ TEMRA [p < 0.05]) (Supplementary Figure 6). Here, CD4 is linked to Glucose intolerance.