While prior studies have shown enrichment of CD8+ over CD4+ T cells in adipose tissue after HIV infection, there is a paucity of data on whether a particular subset of cells underlies this change, and whether adipose tissue T cell profiles differ according to insulin sensitivity in PLWH (as might be expected given prior findings in obesity-related insulin resistance). Here, CD4 is linked to obesity due to melanocortin 4 receptor deficiency.