NFKB2 and Chronic mucocutaneous candidosis: In addition to the Addison-related hyperpigmentation, the major skin manifestations of APECED include chronic mucocutaneous candidiasis, nail dystrophy, alopecia areata or totalis, and vitiligo (45), which collectively closely resemble clinical aspects of p52 haploinsufficiency (Table 3; Figure 3; Supplemental Figure S1).