Of particular interest, in our study, plasma levels of EVs from platelets (CD41+), activated platelets (CD62P+), and pro-coagulant (Annexin V+) origins increased, as a percentage of onset numbers, on the short-term (at 5- and 30-days after acute attacks), indicating a higher number of EVs with pro-thrombotic activity, which may contribute to the increased risk of recurrence of stroke in these patients, including those with no major consequences (TIA). The gene discussed is SELP; the disease is stroke disorder.