Although at onset of attacks, circulating levels of pro-coagulant EVs (Annexin V+) were not different between controls, TIA and AIS (Figure 2), the numbers of Annexin V+ EVs, expressed as a proportion of onset levels, increased with time in both TIA and AIS patients at 5- and 30-days post-attacks (Figure 4H), indicating that the shedding of pro-coagulant EVs increased over time. The gene discussed is ANXA5; the disease is androgen insensitivity syndrome.