We report in the current study that although the total number of EVs did not differ between TIA and AIS patients compared to controls within 48 h of attacks onset, both TIA and AIS patients had higher circulating levels of EVs derived from endothelial cells (CD146+), activated endothelial cells (CD62E+), activated platelets (CD62P+), granulocytes (CD66b+), and leukocytes (CD45+) compared to controls; however, AIS patients had higher numbers compared to TIA patients. This evidence concerns the gene MCAM and transient ischemic attack.