Age at symptom onset (212), BMI (139), bulbar involvement (213), cognitive impairment (214), C9orf72 genotype status (144), respiratory insufficiency (215), “definite ALS” by the El Escorial criteria (216), and functional disability (217) are the most commonly cited determinants of poor prognosis in ALS. Here, C9orf72 is linked to Cognitive impairment.