MFN2 and Charcot-Marie-Tooth disease: Several subtypes of CMT have been identified: mutations of genes encoding myelin-related proteins such as PMP22, P0, and connexin 32 are classified as demyelinating subtype (54); mutations of proteins involved in axonal transport such as mitofusin-2(MFN2), ganglioside-induced differentiation- associated protein 1 (GDAP1), heat shock factor binding protein 1 are classified as axonal neuropathies subtype (54).