Investigation of hepatic tissue expression among fibrosis patients discovered more lncRNAs that were associated with fibrosis such as the HOXA distal transcript antisense RNA (HOTTIP) lncRNA that was elevated in fibrosis patients and even more so in cirrhosis patients (Li et al., 2018), thus implying that HOTTIP expression may indeed represent hepatic injury severity. Here, HOTTIP is linked to fibrosis.