The genome-wide profiling in animal models of liver fibrosis found a liver fibrosis-associated lncRNA1 (lnc-LFAR1) that was upregulated in HSCs and its direct binding to Smad2/3 proteins promoted TGFβ and Notch pathway activation and hepatocyte apoptosis (Zhang et al., 2017). This evidence concerns the gene SMAD2 and Hepatic fibrosis.