Moreover, several small molecules, such as crizotinib (Kwak et al., 2010; Shaw et al., 2013) and alectinib (Seto et al., 2013; Takeuchi et al., 2016; Hida et al., 2017), showed improved survival outcomes in ALK fusion-positive NSCLC patients. The gene discussed is ALK; the disease is non-small cell lung carcinoma.