In parallel to biological process, significant enriched pathways disclosed by six databases including KEGG, Reactome, PID and so on, also closely related to neuronal development (MAPK targets/nuclear events mediated by MAP kinases, gastrin-CREB signaling pathway via PKC and MAPK, G alpha (q) signaling events), neuron transmission (choline metabolism in cancer; phenylalanine, tyrosine and tryptophan biosynthesis, serotonin receptors) and inflammation regulation (JAK/STAT signaling pathway, T cell receptor signaling pathway, interferon–gamma signaling pathway). This evidence concerns the gene CREB1 and cancer.