For Acori Tatarinowii Rhizoma, recent studies revealed that the herbal extracts and related compounds possess anti-fibrillar amyloid plaques, anti-tau phosphorylation, anti-inflammatory, neuronal protection and neuronal nourish effects, which are highly connected to AD-related biological processes and organs (Lam et al., 2017a,b; Song et al., 2018). Here, MAPT is linked to Alzheimer disease.