However, chromatin immunoprecipitation analysis conducted in murine striatal-like cells derived from WT (STHdhQ7) and HD (STHdhQ111) mice did not show differences in CREB/TAF4 binding to the PGC-1α promoter between the two cell types (Cui et al., 2006) suggesting that additional mechanisms may be involved in PGC-1α expression impairment (discussed elsewhere in this review). Here, CREB1 is linked to Huntington disease.