TP53 and hepatocellular carcinoma: However, additional studies conducted in SH-SY5Y neuroblastoma cells upon glutathione shortage, showed that p53 binds to the PGC-1α promoter and positively regulates its expression (Aquilano et al., 2013), while in liver carcinoma cells Hep2G, p53, and PGC-1α proteins interact with each other and modulate their transactivation functions (Sen et al., 2011).