In particular, this study corroborates changes in glioma motility, morphology and cytoskeletal organization with expression of Cx43 (Bates et al., 2007; Crespin et al., 2010), and is also the first study to uncover secretome and ECM mechanisms downstream of Cx43 as a driver of malignancy. This evidence concerns the gene GJA1 and central nervous system cancer.