Our identification of AKR1B10 within the Cx43 secretome provides clues into possible mechanisms of GBM malignancy related to motility/invasion and TMZ resistance (Gielen et al., 2013; Munoz et al., 2014; Murphy et al., 2016; Grek et al., 2018; Wang et al., 2018). The gene discussed is AKR1B10; the disease is glioblastoma.