Enhanced DC number and activity were identified in the gut of Rnf5−/− mice, reflected in (i) increased CD11c+ DCs seen in the  PP of tumor-bearing Rnf5−/− mice, (ii) production of more cytokines and chemokines, (iii) greater induction of T cell cytokines by DCs from GALTs of tumor-bearing Rnf5−/− mice, and (iv) enhanced frequency of CCR7+ DCs and mDCs in GALTs of tumor-bearing Rnf5−/− mice, which coincides with greater migration properties. This evidence concerns the gene ITGAX and neoplasm.