Furthermore, the expression pattern of a number of antimicrobial peptides (AMPs), implicated in the regulation of gut microbiota composition, was markedly reduced in the intestine of Rnf5−/− mice (Fig. 5b), Moreover, we observed increased cell death in organoids prepared from the IEC of tumor-bearing Rnf5−/− mice (Fig. 5c). This evidence concerns the gene ADSL and neoplasm.