Of note, (R)-crizotinib, alone or in combination with CDDP, increased the infiltration of Kras-induced NSCLC by CD8+ cytotoxic T lymphocytes (CTL), yet had no major effect on the local frequency of Foxp3+ regulatory T cells (Treg), meaning that it improved the CD8/Foxp3 ratio in the tumor bed (Supplementary Fig. 8a–h). Here, KRAS is linked to neoplasm.