Of note, (R)-crizotinib was more efficient than its enantiomer (S)-crizotinib in inducing CALR-RFP redistribution and pyknosis in U2OS cells (Fig. 1c, d), as well as in mouse fibrosarcoma MCA205 and lung adenocarcinoma TC1 cells (Fig. 1d). Here, CALR is linked to lung adenocarcinoma.