The combination of (R)-crizotinib, CDDP and PD-1 blockade achieved a 100% cure rate (15 out of 15 mice) in yet another orthotopic NSCLC model, namely Lewis lung carcinoma-1 (LLC1) tumors forming after intrathoracic injection (Supplementary Fig. 17g, h). Here, PDCD1 is linked to non-small cell lung carcinoma.