We firstly found that only basal and HER2 positive breast cancer present higher HIF-1α expression either according to HU subtype or PAM50 subtype among six distinct groups, namely, basal, HER2 positive, luminal A, luminal B, normal-like, and non-classified breast cancer, by using GOBO online analysis (co.bmc.lu.se/gobo) (p < 0.00001, Fig. 1a upper row). The gene discussed is ERBB2; the disease is breast cancer.