The knockdown of UCA1 leads to the inhibition of CXCR4 expression in PC-3 cells (Figure 2B), while overexpression of UCA1 results in the significant up-regulation of CXCR4 in DU-145 cells (Figure 2C), suggesting that UCA1 is able to regulate CXCR4 in PCa. This evidence concerns the gene CXCR4 and posterior cortical atrophy.