Although DNMTs’ levels were not affected by low doses of RG108, higher concentrations (1 and 10 μM) of RG108 reduced the expression of Dnmt1 but not that of Dnmt3a or Dnmt3b, similar to that reported previously in cancer cells (Savickiene et al, 2012; Gracia et al, 2014), suggesting that RG108 is relatively specific to Dnmt1 in the NSC97Q cells (Fig 2H). This evidence concerns the gene DNMT3A and cancer.