The diagnosis of CLL was confirmed for each patient by Flowcytometry (EPICS XL Beckman Coulter flow cytometer, Miami, FL, USA), standard protocol of Beckman Coulter [20] was used in fluorescent dye labeled monoclonal antibody for CD5, CD10, CD19, CD20, CD22, CD23, FMC7, and diagnostic score was assessed by Matutes et al. [21], Absolute B Lymphocyte count obtained by Flowcytometry and Complete Blood Count, was performed using automated hematology analyzer (SYSMEX KX-21N, Japan), Total WBC, Absolute Lymphocyte Count, Hemoglobin level, RBC and Platelets were recorded. Here, MS4A1 is linked to B-cell chronic lymphocytic leukemia.