Nevertheless, the IFNa response is dependent on the MPN subtype, with IFNa monotherapy inducing complete hematologic remission (CHR) rates of 76% and complete molecular remission rates of 18% in Ph neg MPNs such as PV or ET [38], but no more than 55% CHR rates in CML [39, 40] and much lower rates in overt PMF [41, 42]. The gene discussed is IFNA1; the disease is myeloproliferative neoplasm.