Importantly, GEP of CD34-positive cells of BCR-ABL-positive [34] and JAK2V617F-positive [37] MPN patients confirmed differential ISG expression patterns (Fig. 1e), observed in our 32D cell model system and the PBMCs, demonstrating that these changes were not simply due to different cell subpopulations or aberrant murine cell physiology. This evidence concerns the gene ABL1 and myeloproliferative neoplasm.