TGFB1 and hereditary elliptocytosis: The aims of this study were to determine if a more specific neutralizing antibody against TGFβ1 could attenuate neuroinflammation and the neurological complications of acute liver failure and to clearly delineate the role of TGFβ1 signaling in neuroinflammation and the development of HE using tissue-specific knockout mice and in vitro cell culture studies.