SIX5 and chronic obstructive pulmonary disease: We found 5 loci (in MACF1, SYNPO2L, RIN3, TNS1, and MLN) for COPD/RHR (Additional file 1: Table S15), 4 loci (NR0B2, C1orf172, MAFC1, and TNRC6A) for COPD/HBP (Additional file 1: Table S16), and 7 loci (CD3EAP, C19orf83, GIPR, FBXO46, AC074212.3, SIX5, and DMPK) for COPD/CAD (Additional file 1: Table S17) in which the credible set included exonic missense polymorphisms.