The top significant locus was near ARHGAP42 (sentinel SNP: rs633185, Pmeta = 1.80 × 10− 47) [40], Notably, rs7655625, the most significant SNP for COPH/RHR, also had strong correlation with COPD/HBP (Pmeta = 9.69 × 10− 19). This evidence concerns the gene ARHGAP42 and chronic obstructive pulmonary disease.