The Hisayama Study which was a 5-year follow-up study of the 2424 Japanese subjects in the general population (1042 men and 1382 women aged over 40 years) free from CKD at baseline reported that the multivariable-adjusted ORs (95%CI) for developing CKD (eGFR < 60 mL/min/1. 73m2 assessed by serum creatinine [19] or urine albumin-creatinine ratio ≥ 30 mg/g) were significantly increased with higher SUA levels within the normal range [SUA ≤4.0 mg/dL: reference, SUA 4.1–4.9 mg/dL, 1.22 (0.87, 1.72); SUA 5.0–5.8 mg/dL,1.57 (1.11, 2.22); SUA ≥5.9 mg/dL, 2.18 (1.49, 3.18)] [2]. This evidence concerns the gene ALB and chronic kidney disease.