Further evidence of cholangiocarcinoma and/or hepatocellular carcinoma in this PCK model was evidenced by rich cytokeratin 7 staining restricted to intrahepatic ducts in the PCK rat (Figure 11) and corroborated by Ca19-9 staining of both intrahepatic ducts and hepatic parenchyma in the PCK but not WT cohort (Figure 11). Here, KRT7 is linked to hepatocellular carcinoma.