Both variants (CYP2C19*2 and ABCB1) were significant independent predictors of cardiovascular death, ACS, or stroke (ABCB1 3435 TT vs. CT/CC, HR 2.01, 95% CI: 1.30–3.11, p = 0.0017; CYP2C19 LOF alleles carriers vs. non-carriers, HR 1.77, IC95%: 1.11–2.80, p = 0.0155). This evidence concerns the gene ABCB1 and Stroke.