HMGCR and malignant colon neoplasm: A recent study has reported that an increase of leucine in NCI-H716 human colon cancer cells can result in downregulated expression of genes related to the transport and combination of intestinal fatty acids, such as Niemann-Pick C-1-like-l protein (NPC1Ll), acetyl-co-enzyme A carboxylase (ACC), FAS, sterol regulatory element-binding protein-2 (SREBP-2), 3-hydroxy-3-methylglutaryl- CoA reductase (HMGCR) and fatty acid transport protein 4 (FATP4), further decreasing the synthesis of fat [37].