KLRK1 and neoplasm: Skov and colleagues also demonstrated that the treatment of tumor cells with PXD101, suberoylanilide hydroxamic acid (SAHA), and trichostatin A, three HDAC inhibitors, induce MICA/B expression on Jurkat T cells by activating GSK-3 kinase signaling [217] and becoming targets for NKG2D-expressing cells like NK cells (Figure 4E).