Accordingly, in vitro studies using histone deacetylase (HDAC) inhibitors, including valproic acid, have demonstrated its ability to upregulates MICA/B and UL16-binding protein (ULBP) 2 on MM cells by inducing the phosphorylation of ERK 1⁄2 and in turn promoting their lysis by NKs [216] (Figure 4E). This evidence concerns the gene MICA and Miyoshi myopathy.