Moreover, Li et al. demonstrated that NK cells derived from human iPSCs expressing the transmembrane domain of NKG2D, the 2B4 co-stimulatory domain, and the CD3z signalling domain display a higher anti-tumor ability compared with PB-NK cells and T-CAR-iPSC-NK cells in an ovarian cancer xenograft model [225]. This evidence concerns the gene KLRK1 and neoplasm.