CD19 and B-cell chronic lymphocytic leukemia: Most of the studies using CAR-engineered NKs have addressed their attention on CAR against CD19 and CD20 targeting B cell malignancies [226], demonstrating that CAR-expressing NK-92 cells effectively kill chronic lymphocytic leukaemia (CLL) cells and that such a cytotoxic response is significantly higher than that resulting from ADCC mediated by mAbs [226].