These small molecules consist of a single heavy (VH) and light chain (VL) of the variable region of CD16 linked to one (BiKE) or two (TriKE) variable portions of several tumor antigens (Figure 4D), including CD20 and CD19 for non-Hodgkin’s lymphomas [203,204,205,206], CD19 and CD33 for different types of leukemia [207], CD30 for Hodgkin’s disease [208], EGF-R for EGF-R+ tumors [209], HER2/neu for metastatic breast cancer [210,211] and EpCAM for prostate, breast, colon, head, and neck carcinomas and MOV19 on ovarian cancer [212]. Here, ERBB2 is linked to leukemia.