The regulation of JMJD2B in a HIF-1α-dependent manner during hypoxia increases the invasiveness of colorectal cancer cells by reducing the levels of the repressive mark H3K9me3 in genes like ELF3 (E74-like ETS transcription factor 3) and IFI6 (Interferon Alpha Inducible Protein 6) [51]. Here, IFI6 is linked to colorectal cancer.