ETFA and Fabry disease: The only report so far of TOF-SIMS analysis of human kidney biopsies was performed by our group in the context of Fabry disease [66], an X-linked disorder characterized by accumulation of Gb3 and Ga2 in the renal cortex due to a deficiency in α-galactosidase A. Our approach was able to detect both sphingolipid molecules characteristic of this pathology in human material [67].