In line with the reports about the anti-inflammatory effect of TSG [5,10,12], the results of the present study showed that TSG treatment reduced hepatic inflammatory cell infiltration through the detection of CD68-positive Kupffer cells, and serum and hepatic mRNA levels of IL-6 and TNF-α, as well as ICAM protein expression, which may contribute to its protective effect on NASH. Here, IL6 is linked to metabolic dysfunction-associated steatohepatitis.