GPT and metabolic dysfunction-associated steatohepatitis: These mice develop 4 of 5 criteria of human metabolic syndrome criteria and recapitulate all of the key characteristics of human NASH, including hepatic steatosis, rampant inflammation and fibrosis, underscoring the importance of oxidative stress and age-dependency, which mediate NASH-associated hepatic injury (ALT and AST) [16,19].