TP53 and neoplasm: Single-cell RNA-seq (scRNA-seq) of tumor-infiltrating T cells from mice harboring KrasG12D concurrent with P53 loss (KP) treated with ACY-1215 showed upregulation of T-cell activation and T-cell receptor signaling genes, including Cd69, Cd44, Cd247, and Zap70. Single-cell RNA-seq of tumor-associated macrophages among myeloid cell populations, showed that ACY-1215 treatment induced the expression of key genes related to MHC class II expression, such as Cd74 and H2-Aa, when comparing to vehicle treatment in genetically engineered mouse models of non–small cell lung cancer [51].