IGF1 and fetal growth restriction: Most of these newborns showed completed catch-up growth up to the age of two years old.78, 79 Newborns with fetal growth restriction exposed to maternal gestational disease such as hypertension may develop the same maternal pathologies by previous exposure to the risk factors of metabolic disorders.63, 80 Leptin and IGF-1 may be predictive for newborns that will make the catch-up growth, and thus could be characterized as biomarkers of growth and as a prognostic tool in the neonatal clinic.