NPC1 and coronary artery disorder: Rare nonsense mutations in the PCSK9 (proprotein convertase subtilisin/kexin type 9) gene was noted in 2.6% of blacks and associated with a 88% reduction in risk for CHD.12 Also, NPC1L1 (NPC1 like intracellular cholesterol transporter 1) rare inactivating variants are observed 1 in 650 individuals and linked to a 53% relative risk reduction for CHD.13