APOB and coronary artery disorder: Among MIGen individuals free of CHD, we found that APOB PTV carriers had 43 mg/dL lower LDL-C (95% CI, −59.4 to −26.9; P=2.1×10-7), 53 mg/dL lower total cholesterol (95% CI, −72.4 to −34.3; P=4.2×10-8), 4 mg/dL higher HDL-C (high-density lipoprotein cholesterol; 95% CI, −0.39 to 8.8; P=0.07), and 32% lower triglycerides (95% CI, 15%–45%; P=5.0×10-4; Table 2).