DUSP1 and hearing loss disorder: Thus, the cochlear phenotype of the Dusp1 null mouse reproduces that reported for human ARHL, and shares characteristics with other animal models of progressive hearing loss (Dubno et al., 2013; Espino Guarch et al., 2018; Riquelme et al., 2010), including increased apoptotic cell death in the ageing cochlea (Sha et al., 2009).