More broadly this is relevant, given a priori evidence demonstrating a relationship between disruption to the cholinergic system and cognitive fluctuations (Ballard et al., 2002a,b; Pimlott et al., 2006; Colloby et al., 2017) as well as remediation of this symptom with cholinesterase inhibitor treatment in Lewy body dementia (Onofrj et al., 2003). The gene discussed is BCHE; the disease is Lewy body dementia.