RND3 and SGCD were the overlapping genes of the three diseases, which has also been reported in previous studies.19, 20, 21, 22, 23 Negative regulation of apoptotic process and negative regulation of transcription from RNA polymerase II promoter RNA were identified as the two overlapping biological functions among T2DM, CML, and PCa, which may provide novel insights into future studies. This evidence concerns the gene RND3 and type 2 diabetes mellitus.