In summary, SGCD and RND3 were the main gene‐to‐gene relationship among T2DM, CML, and PCa; apoptosis, development, and transcription from RNA polymerase II promote processes were the main functional connections among T2DM, CML, and PCa by network enrichment analysis. This evidence concerns the gene RND3 and chronic myelogenous leukemia, BCR-ABL1 positive.