SGCD and RND3 were the main gene‐to‐gene relationship among T2DM, CML, and PCa; apoptosis, development, and transcription from RNA polymerase II promote processes were the main functional connections among T2DM, CML, and PCa by network enrichment analysis. The gene discussed is RND3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.