As shown in Figure 4D,E, the ratio of p‐PI3K/PI3K and p‐Akt/Akt was reduced by PCAT6 knockdown while increased by miR‐204 inhibition; the effect of PCAT6 was partially abolished by miR‐204 inhibition, indicating PCAT6 affects CRC cell chemoresistance through miR‐204; HMGA2/PI3K signaling is involved in this regulatory process. This evidence concerns the gene AKT1 and colorectal carcinoma.