Non‐coding RNAs (ncRNAs), could exert an extensive series of biological effects through forming interaction network,32 such as miRNA‐miRNA synergistic network.33 Moreover, lncRNA has been reported to target miRNAs, thus interacting with miRNAs and participating in either normal physiological processes or pathogenic processes.34 We revealed that miR‐204/HMGA2 axis modulates CRC cell sensitivity to 5‐FU;5 herein, we investigated whether PCAT6 could interact with miR‐204, thereby affecting CRC chemoresistance to 5‐FU. This evidence concerns the gene HMGA2 and colorectal carcinoma.