TTR and dementia: In a study of 2605 AF patients, decreasing categories of TTR were associated with increased dementia risk (vs >75%): <25%: hazard ratio (HR) 5.34, P < 0.0001; 26%‐50%: HR 4.10, P < 0.0001; and 51%‐75%: HR = 2.57, P = 0.001.6 The risk association was observed in patients exposed to both under‐ and over‐anticoagulation.6