ILC2 are implicated in AD, with AD skin lesions showing higher expression of ILC2 genes RORA, IL1R1, IL17RB, TSLPR, and AREG, and increased numbers of ILC2.25, 27 We have reported elevated ILC2 in skin blisters of AD patients with mutation in FLG. 11 Here, mice deficient in ILC2 developed significantly ameliorated acute skin inflammation but despite the higher numbers of ILC2 present in the skin of Flgft/ft mice,11 ILC2 play a redundant role in the pathogenesis of chronic dermatitis. Here, FLG is linked to Alzheimer disease.