Atopic dermatitis in humans is generally accompanied by an increase in type 2‐ and type 17‐associated cytokines,61, 62, 63 with IL‐13 and IL‐5 reported as important systemic biomarkers for infant AD.64 Indeed, analysis of cytokines in the skin of Flgft/ft mice revealed a significant increase of IL‐4, IL‐5, IL‐9, IL‐13, IL‐17A, and IL‐22 (Figure 4A,B). This evidence concerns the gene IL22 and atopic eczema.