Polymorphisms in members of the IL‐1 family of cytokines and their receptors are associated with skin disorders, such as cutaneous lupus erythematosus, psoriasis, and atopic dermatitis.34, 35 We have previously reported increased IL‐1α, IL‐1β, and IL‐1R1 expression in skin of Flgft/ft mice and AD patients with mutations in FLG. 36. Here, IL1B is linked to cutaneous lupus erythematosus.