In particular, neutrophil‐ and mast cell–derived proteases play prominent roles in the extracellular processing of IL‐1‐family cytokines,91, 92 with human mast cell protease 1 shown to process pro‐IL‐1.93 Increased mast cell chymase activity may therefore contribute to IL‐1β maturation in the Flgft/ft model; however, further investigations are required to fully understand the role of mast cell proteases in AD. This evidence concerns the gene IL1B and Alzheimer disease.