Etiology of AD is multifactorial including genetic predisposition, environmental factors, and immune status, leading to a high complexity in clinical presentation.1, 2, 3 Predisposing genetic factors for the development of AD include mutations in genes affecting the integrity of the skin barrier, such as mattrin (TMEM79) and filaggrin (filament aggregation protein, FLG).4, 5, 6 Filaggrin mutations were found in 30% of AD patients in Poland,7 China (26.0%),8 and Korea (15.7%),9 while healthy individuals had none. Here, FLG is linked to Alzheimer disease.