WRN and Hutchinson-Gilford progeria syndrome: Notably, mutations in LMNA and WRN genes lead to aberrant splicing product progerin and protein loss in human premature aging disorders Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS), respectively (Kudlow et al., 2007; Liu et al., 2011a, b; Zhang et al., 2015).