Likewise, the level of PLAU also increased significantly from NOM (51.80 ± 10.727%) through OED (194.54 ± 46.321%) to HNSCC samples (199.61 ± 47.895%), there was a significant difference in the mean LS of SERPINE1 or PLAU between NOM and OED (p = 0.000) or HNSCC samples (p = 0.000), respectively; however, the LS of SERPINE1 or PLAU between OED and HNSCC had no significant difference. The gene discussed is SERPINE1; the disease is head and neck squamous cell carcinoma.