When we specifically focused on ALS-associated proteins, we found that a number of FUS interaction partners encompassed RBPs previously described to cause familial forms of ALS, including hnRNPA1, hnRNPA2B1, EWSR1 and TAF15, were reduced in pulldown samples with P525L FUS compared to WT. Here, HNRNPA1 is linked to amyotrophic lateral sclerosis.