Consistently, PRRT1 knockout mice mice show reduced extrasynaptic AMPARs, but also weaker synapses, impaired tetanus-induced (but not theta-burst induced) LTP, and cognitive impairments, suggesting that PRRT1 is required for specific forms of synaptic plasticity, possibly by ensuring the existence of a sufficient pool of extrasynaptic AMPARs [370]. Here, PRRT1 is linked to Cognitive impairment.