The mechanisms by which corticosteroids reduce vasogenic edema are not completely understood,9 but may be mediated by VEGF (vascular endothelial growth factor).10 On this basis, bevacizumab, an anti‐VEGF monoclonal antibody, has been used to improve clinical symptoms and edema associated with cerebral radiation necrosis.11 Interestingly, bevacizumab may be synergistic with ipilimumab against metastatic melanoma by augmenting immune cell infiltration of tumors.12 This evidence concerns the gene VEGFA and metastatic melanoma.