However, some studies have shown that certain anticancer agents which are not ICD inducers, are also able to elicit DAMP emission.38, 39 For example, Dudek‐Perić et al. showed that melphalan, a chemotherapeutic drug, could cause increased surface CRT, HSP70, and HSP90 in melanoma cells, but was not strongly ICD inducing when subject to evaluation in mice.38 Additionally, it is still unclear how much CRT expression is needed to elicit an anticancer immune response. The gene discussed is CALR; the disease is melanoma.