They regulate anticancer immune responses either via the expression of inhibitory checkpoint molecules or via the production of immunoregulatory cytokines, such as TGF‐β, IL‐10, IL‐4, IL‐13, or IDO.186, 187 In order to improve cancer immunotherapy, it is important to understand the TME and overcome its immunosuppression. Here, TGFB1 is linked to cancer.