For example, the immunosuppressive TME of pancreatic cancer was improved by codelivery of an IDO inhibitor and oxaliplatin using a lipid bilayer‐coated mesoporous silica nanoparticle (MSNP) (Figure15).192 By integrating IR780 and IDO inhibitor NLG919 into MPEG‐PCL micelles, Qian and co‐workers effectively suppressed the primary tumor and induced an abscopal effect to inhibit the growth of distal tumors.193 Lin and co‐workers developed a chlorine‐based nanoscale metal‐organic framework (MOF) to encapsulate IDO and combined this with immunogenic photodynamic therapy. The gene discussed is IDO1; the disease is neoplasm.