TNFRSF11A and osteoporosis: At the molecular level, deregulation of osteoprotegerin/tumor necrosis factor (TNF) receptor superfamily member 11a (TNFRSF11A/RANK)/RANK Ligand (RANKL), WNT, and bone morphogenetic protein (BMP) signaling pathways provides the basis for osteoporosis and bone fragility onset2.