Reperfusion after cerebral ischemia (R/I) in MetS rats increased MDA, TNF-α, and IL-6 levels, but it decreased the activities of the main scavenger enzymes including SOD, CAT, and GSH-Px and neuron densities in CA2 and CA3 subregions of the hippocampus. The gene discussed is TNF; the disease is Cerebral ischemia.